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KMID : 1145120190170040431
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Asian Journal of Beauty and Cosmetology
2019 Volume.17 No. 4 p.431 ~ p.439
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Anti-inflammatory Effect of Zeaxanthin in RAW264.7 Cells
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Shim Joong-Hyun
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Abstract
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Purpose: This study was performed to test the anti-inflammatory effects of zeaxanthin on skin using RAW264.7 cells.
Methods: The anti-inflammatory effects of zeaxanthin on RAW264.7 cells were assessed by measuring cell viability, mRNA expression, and nitric oxide (NO)/prostaglandin E2 (PGE2).
Results: The anti-inflammatory effects of zeaxanthin were elucidated by analysis of IL1α/IL1β/IL6/TNFα mRNA expression and NO/PGE2 production. Quantitative real-time polymerase chain reaction showed that zeaxanthin decreased the mRNA level of IL6 and TNFα. Additionally, PGE2/NO detection also revealed that zeaxanthin exhibited anti-inflammatory properties.
Conclusion: The results presented in this study suggest that zeaxanthin is an anti-inflammatory compound. Therefore, it could be a potent cosmetic ingredient with anti-inflammatory effects against atopic dermatitis. Further research on the anti-inflammatory mechanisms of zeaxanthin would not only facilitate the development of functional cosmetics but also pharmacological treatments.
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KEYWORD
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Zeaxanthin, Anti-inflammation, PGE2, Nitric oxide, Interleukin
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